How Mindfulness Rewires Your Brain: Neuroscience Insights with Jamey Maniscalco

In this episode of The Mindful Journey, host Sana sits down with neuroscientist, professor, and founder of Manifest Wellness, Jamey Maniscalco. Jamey shares powerful insights into how mindfulness meditation creates real changes in the brain, reshaping attention, emotional regulation, and resilience. He breaks down the science behind mindfulness, discusses how even busy professionals can integrate mindfulness into their daily lives, and shares his personal journey through grief, cancer, and transformation. This conversation offers actionable tools for anyone struggling with stress, anxiety, or overwhelm — showing that mindfulness isn’t a luxury but essential mental maintenance.

About the Guest:
Jamey Maniscalco is a neuroscientist, professor, and founder of Manifest Wellness. His career spans academia, pharmaceutical consulting, and personal coaching. Jamey’s passion for mindfulness emerged after navigating personal loss, his own cancer diagnosis, and the limitations of Western medicine. Today, he helps leaders, parents, and high-performers apply evidence-based mindfulness practices to reduce stress and build resilience.

Key Takeaways:

• Mindfulness strengthens the prefrontal cortex, improving attention and emotional regulation.

• Consistent practice rewires the brain’s default mode network, reducing anxiety and self-judgment.

• Benefits can begin within weeks, but long-term practice offers deeper resilience.

• Even 2 minutes of daily mindfulness can create meaningful change.

• Habit stacking and small consistent steps help busy individuals build mindfulness routines.

Connect with Jamey Maniscalco:

• Website: manifestwellnessco

• Email: jamey@manifestwellnessco

• LinkedIn, Instagram, Facebook: Search “Manifest Wellness”

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